Struggling Udinese has produced the shock of the round to defeat 2nd placed Juventus 2-1 overnight.
Fabio Quagliarella and Antonio Di Natale gave the home side a 2-0 lead before former Udinese striker Vincenzo Iaquinta converted a late penalty for Juventus.
Juventus went into the clash without Alessandro Del Piero, with French veteran David Trezeguet making his return to the side as a second half substitute.
The result has rocked Juventus' Serie A hopes, leaving it six points adrift of league leaders Inter Milan.
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