Manchester United are U21 Premier League champions this season.
The outcome was confirmed by a surprise home defeat for rivals Chelsea, the only team in the table who could still catch Warren Joyce's United side.
The Blues were beaten 1-0 by bottom side West Ham United in dramatic fashion, with Josh Cullen scoring in the 90th minute at Stamford Bridge.
The Reds had edged closer to the title earlier in the week, with an emphatic 4-0 derby win over Manchester City courtesy of goals from Adnan Januzaj, James Wilson, Ashley Fletcher and Matty Willock.