"The only positive thing of the night was that my knee reacted well and I did not feel pain. Everything else goes into the background as far as I am concerned," he said.
He had not played since the game with Reggina on September 21 due to a recurring problem in the knee that underwent ligament surgery earlier this year.
"The most worrying thing now is our position in the table, but with this squad built to go all the way, I think sooner or later we will get back into that leading group."
The Giallorossi have already lost four games this season and their fragile psychological state is hardly ideal for Wednesday's Champions League trip to Chelsea.
"Playing every three days means we have the chance to quickly put this defeat behind us, even if we know it is going to be another very difficult game against a competitive side," said the captain.
"I had faith in a positive result tonight as well, but it didn't go according to plan. Inter improve every year and now have a very talented Coach who gave them another dimension. This is a devastating opponent."