Spurs have a record of one defeat in the last 13 matches in the Premier League.
"It's an important game for everyone, for the fans, for West Ham, for us, sitting in fourth spot and trying reach third, it's a vital game," Holtby told the Spurs website.
"I can't wait and we've two massive games in a row now, West Ham and Arsenal. It doesn't get better than that! I'm already buzzing for those games."