Spurs will be missing striker Emmanuel Adebayor, defenders Younes Kaboul and Jan Vertonghen and midfielder Paulinho as they look to overcome a 3-1 deficit following last week's Round of 16 first leg at White Hart Lane.
"We are struggling," Sherwood told reporters. "We have a lot of injuries, unfortunately.
"We are going to have to leave a lot of bodies behind and go with a few kids.
"Adebayor will be missing, as he has a hamstring problem.
"Jan Vertonghen is obviously suspended so, in the centre-back area, we need to conjure up something.
"Paulinho is going to be struggling, he has pulled out of training this morning with a calf problem. We are going to assess it tomorrow."
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