The 26-year-old spent eight seasons at White Hart Lane but chose to leave in the summer in search of first-team football.
"We're all looking forward to seeing him," Defoe said of Huddlestone, who could play Spurs again in Hull's Capital One Cup tie in midweek.
"He was a great player here and is doing well for Hull, pulling strings and stuff.
"It is going to be a tough game but it is a game we have to win.
"It is important we keep winning football matches. I am looking forward to both games. We're a club that is going places."
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball