Defoe pointed to Sunderland's recent performances against other sides with top-of-the-table ambitions ahead of what promises to be a tricky test in the North East.
"It's another tough one," the striker told the Spurs website. "Look at teams like Man City, who have already lost there. They pushed Chelsea close in midweek as well.
"Every game is difficult and they will be fighting to get a result. They've got a good manager who we know well, of course.
"He has good football knowledge, he's a strong character, he used to play for us and was a coach here too.
"You always know what it's like when you come up against former players or managers."
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball