The Italian was sensationally axed by Blues boss Roman Abramovich today, just months after guiding the club to the FA Cup/Champions League double.
Villas-Boas met the same fate at Stamford Bridge in March and although he feels Di Matteo was harshly done by, he believes that displacing a manager is part and parcel of being involved with the West London club.
"At Chelsea, I think another sacking is just like any other day at the office. That's my interpretation," he said.
"Roberto has achieved so much in such a little amount of time. His CV is maybe one of the best in the world now - he has won the Champions League and the FA Cup too.
"It was difficult for Robbie and I wish him well for the rest of his career.
"Regarding the club, it's their decision, it's what they think will take them forward but other than that I can't comment."