Tottenham boss Mauricio Pochettino has left five of his players behind for Champions League group game away to CSKA Moscow.
Harry Kane, Eric Dier, Mousa Dembele, Danny Rose and Moussa Sissoko have all been left behind in London as Spurs attempt to bounce back from the defeat to Monaco on matchday one.
Kane is sidelined with an ankle injury while Dier and Dembele have been ruled out with hamstring problems after missing Saturday's victory at Middlesbrough.
Rose has not featured for Spurs for a whole month after he picked up a hamstring strain while on international duty with England.
Sissoko made his second Premier League start of the season against Boro but was withdrawn with a head injury in the second half and Spurs have decided not to risk the Frenchman.