Caulker lines up in Spurs' defence just a month after being a target for racist abuse from Serbia fans while playing for the England Under-21s on in a night of shame in Krusevac.
Caulker, 20, added: "I think Lazio will be a tough test - every game so far has been tough. But we are ready for it.
"I feel I am growing up quickly. Obviously there have been a lot of experiences off the pitch. But going out on loan so early, when I was just 17, I had to deal with a lot of off-pitch experiences as well as on-the-pitch ones.
"I am not worried about the atmosphere here. My hopes and aims are that football does the talking. Italy is a great footballing country so I hope that will be the talking point."