Tottenham will play Jamaica in The Bahamas in an official friendly on May 23.
Both teams accepted an invitation from the Government of The Bahamas, and the stage is set for the first match featuring a Premier League Club in the Commonwealth of The Bahamas.
The match will also mark one of the major events in the new 15,000-seat stadium as well as in the year-long celebration of The Bahamas' 40th anniversary of independence.
Tottenham Hotspur Chairman, Daniel Levy, said: "We are delighted to accept an invitation from the Government of The Bahamas to take part in the country's 40th anniversary celebrations. This match will see the Club support the Bahamas Ministry of Tourism, as it looks to build its profile across key markets around the world as a leading destination for tourism."