Spurs were due to face their rivals for a Champions League place earlier in the month but the match was postponed due to snow, with Gerrard and Torres then suffering injuries in the FA Cup defeat to Reading.
Redknapp's own options have been bolstered by the return of Jamie O'Hara as the Premier League's transfer embargo for Portsmouth meant the midfielder could not re-register on loan at Fratton Park.
"I'd be lying if I stood here and said that the absence of Gerrard and Torres won't matter," said Redknapp, ahead of the Wednesday evening fixture.
"Of course, they are two world-class players, and they will miss them.
"But they have a strong squad. I have never been there and had an easy game. It is a difficult place to go."