FA Cup winners Wigan need to win themselves to have a realistic chance of survival.
"Obviously there is great emotion and motivation going through the Wigan players' heads at the moment, and we saw the message from (chairman) Dave Whelan saying they are absolutely focused.
"I expect them to give them a hard game because the objectives are there for both teams. Arsenal are a very experienced side, but Wigan are very, very motivated to save themselves."
"For us the objective was to take this into the last game of the season and that is what we will do," Villas-Boas added.