Thursday night's game had already been overshadowed before kick-off by the shocking and brutal attack on a group of the club's supporters early this morning.
Around 20 men burst in to the Drunken Sailor pub in Campo dei Fiori at around 1am and beat the fans with sticks and glass bottles. One fan is recovering in hospital after being stabbed in the head and leg.
Villas-Boas expressed his disappointment at the attack on Thursday night, saying: "It is an extremely difficult moment for them.
"We have to be aware there is a police investigation and I'm not in control of all facts.
"But there is massive disappointment and the fear they've gone through is hard.
"To point a finger at this point would be incorrect but (we) give them a message of support.
"As a club, we will try to help them overcome this."