Spurs are at AC Milan for their round of 16 clash.
Defoe told the Daily Express: “Wow, can you imagine? A Spurs Barcelona final… Imagine the fans. It would be amazing.
“Once you get through to the quarters – and we are not yet looking past AC Milan – then I believe anything can happen.
“You would approach a quarter-final like a final; win that and you’re in the semis. So yes, it’d be crazy if we can get that far and even go on. You never know with knockout football – there are always shocks over the years.”