West Brom have sacked chairman John Williams and chief executive Martin Goodman as owner Guochuan Lai responded to the club's poor run of form.
The Baggies lost 3-0 at Chelsea on Monday and are bottom of the Premier League table with 11 games left.
A club statement said the changes "follow Albion's poor results".
Both Williams and Goodman "have been placed on garden leave with immediate effect", with Mark Jenkins becoming the club's new chief executive.
A club spokesman said: "We would like to thank John and Martin for all their efforts since their appointments and wish them well for the future."