Liverpool's shock defeat against a phenomenal Swansea City was the story of round 22, but Jurgen Klopp's team were not the only title challenger who lost ground on Chelsea.
Manchester City's 2-2 draw with Tottenham Hotspur has extended the Blues' lead at the top of the Premier League to eight points after Arsenal were able to edge Burnley thanks to a last-gasp Alexis Sanchez penalty.
Chelsea are almost certain to win the title now, with Diego Costa swiftly back in scoring form, but the race for a top-four finish looks set to go the distance.
Only six points separate the five teams behind Antonio Conte's side after yet another difficult weekend for so many of the traditional "big clubs".
Here are 3 things we learnt from the weekend's action:
1) Guardiola's attacking tactics outwit Pochettino, proving his high-risk strategies can work in England
Pep Guardiola's decision-making has been questioned by many throughout Man City's difficult run of results, but his tactical strategy during the opening 45 minutes against Tottenham on Saturday was very good.
This was classic Guardiola: extreme attacking football that pinned back his opponents, creating an open, but one-sided game. City were unfortunate not to win a match in which none of the four goals correlated with the pattern of play.
In a 4-3-3, Leroy Sane and Raheem Sterling played high up the pitch, which often put them three-versus-three against Spurs' disorganised back line (without Jan Vertonghen, there were too many gaps between the three players).
City continually won the ball high up the field and exposed the Spurs defence thanks to some piercing runs from deep; Guardiola clearly recognised that this would be a congested game and thus instructed his wingers to make plenty of inside diagonal runs for a long through-pass – and even instructed Pablo Zabaleta to underlap at every opportunity.
Pochettino's half-time switch to a 4-2-3-1 solved the conundrum of the first half, ultimately leaving the hosts frustrated by their inability to score during that dominant period of the match.
Once again Guardiola's intricate play failed to create enough clear-cut chances, but fans will be encouraged by the bravery of the Catalan's tactics; proof that he is still the most intelligent manager in the division.
2) Clement has managed to get Swansea organised in a very short space of time
The most remarkable thing about Swansea's resilient and hard-working performance on Saturday was their compact defensive shape. Despite having spent just 19 days in the job, Clement has already had a major impact on the training field and, by winning at Anfield, has suddenly made Swansea look capable of avoiding the drop.
His flat 4-5-1 formation was perfectly executed throughout, squeezing Liverpool's central attackers out of the game and forcing them into (largely) harmless wide positions. Fernando Llorente was consistently utilised on the counter-attack and Wayne Routledge broke quickly from the right wing; their three-point counters, going exclusively down Routledge's wing, proved that Clement's obsessive tactical coaching is paying off.
His players have been speaking highly of their new manager over the last week, praising Clement's hands-on approach and the intricacy of his tactical instructions during training.
Clearly the hard work is paying off; Saturday's win represents a stunning turnaround for a team that, defensively, were the most chaotic in the division under Bob Bradley.
3) Slick Southampton possess the quality in midfield needed to climb back up the table
After four successive Premier League defeats, Claude Puel needed a game like this. Leicester City's central midfield has been disastrously flimsy throughout the 2016/17 season, and perhaps unsurprisingly, Southampton ran rings around them.
The win provides a much-needed confidence boost that should prove – to the players as much as anyone else – that they are good enough to climb back into the top eight.
James Ward-Prowse, Oriol Romeu, and Pierre-Emile Hojbjerg gracefully controlled this tie, taking 252 touches and making 170 passes between them. This was simply too much for Leicester, who utilised an unfamiliar 4-4-2 diamond that allowed Claudio Ranieri to play three central midfielders – something he should have tried a long time ago.
Wilfred Ndidi, Nampalys Mendy, and Danny Drinkwater managed a meagre two interceptions between them all match. Leicester must not be disheartened by their failed experiment, however, as they need to continue with a three-man midfield if they are to stop haemorrhaging goals.
Whatever the system, Ranieri was never going to be capable of outmanoeuvring such a classy and in-sync trio at St. Mary's.
Best of the Week - Harry Maguire
Marco Silva once again organised his Hull City team superbly in this match, with Harry Maguire the standout defender in his 3-5-2 – a formation that, as is customary these days, mirrored Chelsea's.
Seven of the last eight teams that have faced the Blues in the Premier League have utilised three at the back.
Maguire certainly did not deserve to be on the losing side. He made eight tackles, eight interceptions, seven clearances, and eight headers in a commanding display from right-centre-back.
Shepherding Eden Hazard throughout, the Belgian failed to complete a single key pass or shot on goal before being hauled off in the 72nd minute. Despite the defeat at 'The Bridge', Hull have every right to feel optimistic about their survival hopes.
Worst of the Week - Loic Remy
Sam Allardyce's decision to trial a 3-5-2 formation made a lot of sense; his full-backs have badly let him down in recent weeks, he cannot afford to drop any of his three central midfielders, and Crystal Palace have two highly-regarded strikers in their squad.
Unfortunately, one of these two didn't show up on Saturday.
Loic Remy has only recently returned from injury and so can be forgiven for looking rusty, but in a 3-5-2, the most athletic of the two strikers must be more involved in build-up play than the Frenchman was against Everton.
Remy did not take a single shot on goal during the hour he was on the pitch, and a shocking 27% of his 29 touches gave the ball back to the opposition.