The 25-year old Arsenal centre-half was included by Swiss boss Ottmar Hitzfeld even though he was given little game time by the Gunners before getting injured whilst on loan at Goodison Park but the coach said his performances in the past at international level where good enough for a call up.
"It's always tricky deciding whether to pick someone who hasn't been playing," Hitzfeld said.
"But Senderos has always repaid us with good performances."
Joining Senderos is Valon Behrami from West Ham as the only other Premier League player in the final squad.
23-man Switzerland squad for 2010 World Cup
Stephan Lichtsteiner (Lazio) Stephane Grichting (Auxerre) Steve Von Bergen (Hertha Berlin) Philippe Senderos (Arsenal) Mario Eggimann (Hannover) Christoph Spycher (Eintracht Frankfurt) Reto Ziegler (Sampdoria)
Valon Behrami (West Ham) Gokhan Inler (Udinese) Benjamin Huggel (Basel) Gelson Fernandes (St. Etienne) Xherdan Shaqiri (Basel) Pirmin Schwegler (Eintracht Frankfurt) Tranquillo Barnetta (Bayer Leverkusen) Marco Padalino (Sampdoria)