The Swans conceded a goal in the last minute to suffer a 2-1 defeat against Watford on Saturday, with Mesa partly culpable for the concession after carelessly giving the ball away.
Clement said: "I have not said anything to Roque as an individual, I don't necessarily think that is something that I need to point out. It was glaringly obvious to everybody that saw the game, including him. He knows he made a mistake there.
"But I have to say he played very well the rest of the time he was on. In some cases there is a need to feedback on things, but in others there is no point because it is glaringly obvious."