The 34-year old German gloveman has been in decent form for the Swans over the past eight matches in place of the injured Michel Vorm and he admits host the Red Devils is a dream come true.
"It would be a dream to play against Manchester United," Tremmel told the club's official website, "but, in all fairness, I've played a lot of big games against top teams in the last few weeks. Tottenham, Liverpool, Arsenal, Chelsea — those experiences will help me.
"I am not afraid of Manchester United. Of course, it is a big story to play against them but they just have 11 players. They have good players but so have the other teams.
"We played Manchester City, who have magnificent offensive players, but we only conceded one goal. I believe we will do a great job, especially because we are at home.
"We also have a good team so why can't we get something out of the game?"