Poyet is confident Uruguay's prolific strikeforce of Luis Suarez and Edinson Cavani will strike fear into World Cup opponents in Brazil next summer.
He said: "If you have special players up front you're very difficult to beat.
"They say in England you're as good as your two strikers, and in Cavani and Suarez you've always got a chance.
"They're not a one man team, they've got a good system and they're difficult to play against, they're annoying to play against.
"They have the commitment and the way they play and two good strikers, it used to be there with Diego Forlan who used to be on fire as well but now he's not playing so much."