Balotelli faces his former club for the first time.
Stramaccioni said: "Balotelli is a strong player, but there are many champions at Milan. M'Baye Niang is a very talented young player, while Kevin-Prince Boateng can be decisive on his day. We have more experience, but whatever happens both sides will stay in the fight for a Champions League spot.
"These are two huge teams in a city that lives for football. We hope to provide a spectacle, as always."