The former Arsenal No1 watched from the bench as two second half goals from the experienced Italian giants knocked Spurs out of the competition.
When heading down the tunnel, the 27-year-old looked up into the stands and gestured for the home fans to 'keep their chins up'.
But it didn't end there.
He then took to Instagram to upload a picture of the Juventus players in celebration with the caption: "Great win and celebrations vs one of the best teams in North London. #NorthLondonIsRed."
Szczesny telling the Spurs fans to keep their chin up once a Gooner..... pic.twitter.com/fKMEecpUbC— Juvefc.com (@juvefcdotcom) March 7, 2018
That moment when Szczesny mocked entire Spurs fanbase ;) pic.twitter.com/aTPoVffbVC— Juventus India (@JuventusIndia) March 8, 2018