The French international joined the Gunners from Sevilla a fortnight ago and made his first appearance for the club in a reserve team win over Blackburn on Tuesday.
Squillaci came through the game unscathed - although his ego may have taken a hit by the three goals conceded in a 4-3 win - and he has told his manager that he is ready to be thrown in at the deep end on Saturday.
"Yes of course I'm ready to play against Bolton," the 30-year-old said through an interpreter on the club's official website. "But it depends on the coach and other players. If I want to play I must work hard during training.
"I played 90 minutes for the reserves and felt good physically. Little by little I am picking up the rhythm. I played the whole game and afterward I didn't feel too tired which is a good sign.
"It was quite a hard game, but we ended up winning the match which is positive. I thought we played very well but it was a real shame to concede three quite avoidable goals.
"I am happy enough with my performance but I could have played better, that is for sure, so I will keep working hard to find my form."