Adebayor is on-loan at Spurs from City.
"They have two players going to the African Nations Cup. Kolo Toure is not playing a lot but he is a great player," Adebayor said. "Yaya Toure has been amazing for them this year.
"We will have to wait and see (how they cope). In football you can have two or three injuries in a week. That has happened to us recently.
"City have a great team, a great spirit and at the moment they are playing good football, but if they got a couple of injuries I think it would be very difficult for them."