Spurs are set to play their European fixtures at the national stadium this season, beginning their campaign against Monaco on Wednesday night, and will be suited by the wider expanses according to Pochettino.
"We need to go there and behave naturally," the Argentine said.
"We will have the same routine as we do at White Hart Lane - arrive three-and-a-half hours before the game, have some meetings, prepare for the match in a normal way.
"We trust ourselves and the way we play. It is a good chance for us to play on a big pitch but in the end we need to adapt, not find excuses.
"When you play on a big pitch it can help a team who try to build from the back, as we do, because you have more space.
"Yes, it is bigger than White Hart Lane but we are not worried about our physical condition."