Villas-Boas heaped praise on Defoe after the striker equalled Martin Chivers' club record of 22 European goals.
The 31-year-old's deflected effort helped to secure a hard-fought 2-0 win at Sheriff Tiraspol, putting Spurs on the cusp of qualification to the Europa League knockout stages.
It was Defoe's sixth in the competition this season and saw the England international move level with Chivers in the club's record books.
"It is some achievement," the Portuguese said. "If we continue like this, there is a big chance he will break the record.
"It will be another great achievement for him. I am sure he will achieve it.
"Let's not celebrate it before it happens, but it will be a great record for him and the club. It was another great performance by Jermain."
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