The North London side lost the first leg of the tie 1-0 in Belgium, and they will need to overturn that deficit to ensure their progression to the Round of 16.
"We need to make Wembley home," said Pochettino.
"The last game was good for us. We played well and started to feel better.
"For us, it is perfect to play there. It is not confirmed, because the club has not yet confirmed, but we hope we play there next season because that will show we are very close to finishing our stadium."