Wenger was jeered by his own fans after their draw at home to Fulham last Saturday.
And that did not go unnoticed by Spurs boss AVB ahead of his side's trip down the Seven Sisters Road.
He said: "It is something we will try to exploit.
"You saw at Manchester City last week that when we scored the crowd got very nervous until they equalised. So we must try to recreate the same environment." Villas-Boas admits he is surprised at the stick Wenger has been receiving - despite the Gunners' seven trophy-less years.
AVB added: "He has delivered what Arsenal want for the last years and continues to be one of the great managers."