Defoe's double against Wolves took his tally to 99.
He said: "If I score my 100th goal for Tottenham on Wednesday night there will be a reason why.
"I say that because I always believe things happen for reason but it would be nice to do it.
"It's been a long while since I scored my last Premier League goal. More than anything, it has been frustrating.
"As a forward when you are scoring goals, you are full of confidence and buzzing about. When you are not scoring your game changes, you start snatching at things or take an extra touch because you want to be so precise.
"But I've always tried to get into the right positions to score and I'll never stop doing that and it was good to get the two at Wolves."