"The lads put in a great performance, especially as they were facing a good team," said Spalletti. "The red card increased our difficulties, but we remained in the game and managed to maintain our balance, which was not easy.
"It is an encouraging result, but I would have preferred to win it, as the right circumstances were in place. Considering the way the match went overall, I guess it is a result we can be content with."
Sampdoria are kicking themselves after wasting such a golden opportunity to progress and must now win at the Olimpico on January 30 or draw by scoring at least two goals.
"I would have liked to end this match with the victory we deserved," said Samp coach Walter Mazzarri.
"After that Mexes incident we did not allow Roma anything. At the end we were tired, but considering the story of the game I think we deserved the win."