Barcelona midfielder Sergio Busquets is up for the challenge.
Busquets said: "We all know what a great player Cristiano is. He'll spend a lot of time on Arbeloa's side, but you need to work together as a team to stop a player like him."
Spain coach Vicente Del Bosque was also well aware of the test facing his side.
He said: "It's tough trying to stop a player with his qualities. He's extremely dangerous both when he has space and without it."
Defender Gerard Pique agreed, adding: "He's one of the best in the world and if we want to stop him it will have to be a collective effort."