The Republic of Ireland will face World and European champions Spain in a friendly in New York's Yankee Stadium on 11 June.
Spain hammered the Republic 4-0 on the way to winning Euro 2012 last summer.
Republic of Ireland boss Giovanni Trapattoni said he was "looking forward" to the New York game.
"Our team is in evolving and showing a lot of promise," added the Italian.
"The recent games demonstrated that our players have serious potential.
"Matches against opposition like England, Georgia and Spain are very helpful to that development and great preparation for our important competitive fixtures in June, September and October."