SkySports is reporting that Southampton's executive chairman Nicola Cortese is understood to have handed in his written resignation.
If Cortese's departure is confirmed, Saints boss Mauricio Pochettino's future could be in serious doubt.
Cortese considered leaving St Mary's in May of last year after stressing to owner Katharina Liebherr that he was concerned about the future direction of the club.
At the time, Pochettino stressed that his involvement at Southampton was dependent on his chairman remaining at the club.
There has so far been no comment from Southampton.
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