Puel, who will travel with the Saints to Emirates Stadium on Saturday, has hailed the significance of Wenger to the North London club and has labelled him as an 'example' to other managers.
"It is the first time we can play one against one," said Puel of his fellow Frenchman.
"I haven't met him in an international game or the Champions League for example.
"It is the first time we can see a game with this situation but it's a pleasure of course. I think he's fantastic - Arsene is an example for all.
"Twenty, I don't know how many, years he has stayed at Arsenal with fantastic results. He played every season in the Champions League."