Saints have an outside chance of making the cut for the competition either through the FA Cup or the league.
"It hasn't changed. In my opinion the Europa League is not an attractive competition," said Pochettino.
"That is my personal opinion, I'm not talking about anyone else, it's my personal opinion and as Mauricio Pochettino there is no interest in the Europa League.
"The ambition of course is to one day play the Champions League and that I would be interested in.
"That is my opinion, not the club's opinion.
"I think it is a competition that kills you and if you don't get to the final and win it then you don't get anything out of it so it's a tough competition in that sense."