Southampton boss Ronald Koeman could hand starts to Steven Caulker and Oriol Romeu for tonight's Europa League tie with Midtjylland.
Former QPR defender Caulker missed last Saturday's 3-0 defeat to Everton.
Romeu signed in a £5m deal from Chelsea last week.
Manager Ronald Koeman said: “He's fit enough. He had a normal pre-season.
“Of course he didn't have really that intensity in the level of games in the friendlies, but he is ok, he is fit to play, he needs rhythm, game time, that's for sure, but we will give him that."