Just like at Manchester City two weeks ago, his side gave up a 2-1 advantage to lose 3-2 and, while frustrated, the Saints boss was keen to highlight the positives.
"For a newly-promoted club we have scored two goals in open play against a Man Utd side packed full of experience," Adkins said.
"I thought they had worked very hard and we made the substitutions to bring more energy into the side.
"You get punished at the highest level. [Nathaniel] Clyne slips and Van Persie puts the ball into the net.
"In the second half, we were buzzing. But they kept possession of the ball. It's two corners we have conceded from."