After 11 years and 366 appearances for the club he joined for a bargain £1.5million from Norwegian side Molde, Solskjaer has had to finally call it a day due to an ongoing knee injury.
Striker Solskjaer, who famously scored the winner in the Champions League final against Bayern Munich to help the club win the treble in 1999, has made several comebacks in the last four years.
However, the man famously nicknamed 'the baby-faced assassin’ will remain at United in a coaching capacity and will continue to represent the club as an official ambassador.
Although it is a sad day for the 34 year old, he appreciates he has had a fantastic career, scoring 126 goals overall.
"I would like to thank the manager (Sir Alex Ferguson), the coaching and medical staff, and most of all the supporters who have supported me through my career," said Solskjaer.
"They have been fantastic and were a real inspiration to me when I was out injured.
"The support they and the staff showed me during that time was the main motivation for me making my comeback.
"I feel proud to have represented Manchester United for 11 years, and have some very special memories."
His fondest, though, will always be scoring on his debut just six minutes after coming off the bench to secure a 2-2 home draw with Blackburn on August 25, 1996
"I've been asked many times what's the greatest moment of my United career," said Solskjaer.
"Scoring that goal in my first game and turning round to see that Eric Cantona was the first one coming towards me to celebrate, that just made me realise, 'I'm at Old Trafford now'."
With great irony, his last goal was also after coming on as a sub against Blackburn at Old Trafford in March, scoring in the 90th minute of a 4-1 win.