With Thursday's game delicately poised, Simao admits Atletico are approaching it as a one-off as they look to book their place in next month's final in Hamburg.
He told as.com: "This is a semi-final but for us it is like a final.
"We must have faith, we are in the final 90 minutes.
"Moreover, we have a one-goal advantage and we know what playing at Anfield is like because last year we played there in the Champions League.
"We are ready and focused. We are optimistic. We will play our game."