The Hoops host the Italian giants in the first leg at Parkhead on February 12 and Greek forward Samaras feels they have every chance of causing an upset like they against Barcelona in the group stage.
"At Celtic, we've had more or less a settled side for three years," he said.
"We're a young team, but we are confident in our ability to do well in the Champions League.
"When you look back and see our aggregate score against Barcelona was 3-3, you deserve to be confident.
"We respect Juventus, but there's no reason why we can't do something really good."