Rooney hit the landmark during victory over Bayer Leverkusen.
"It's a great honour for me to have scored 200 goals for a club like Manchester United," he said on officialwaynerooney.com.
"When you look at the list of top scorers I'm only the fourth player in the club's history to have reached this number after Sir Bobby Charlton, Denis Law and Jack Rowley.
"It's certainly something I'm very proud of.
"My main aim is always to help the team win games and if I score that's a bonus. Hopefully there are still a few more goals to come from me yet."
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