Liverpool boss Brendan Rodgers could play Raheem Sterling as a central striker at Manchester United.
The Daily Mail says Sterling has been trialled as the main striker, with Rickie Lambert struggling to fill the berth.
Rodgers may even switch to playing with a back three - though the final decision will be made on Sunday morning - and Adam Lallana is expected to start.
Liverpool have struggled to cope with the sale of Luis Suarez and the absence of Daniel Sturridge through injury this season.
The Anfield club are desperate for a result after a morale-sapping exit from the Champions League on Tuesday and their failure to challenge for the top four this season.