Fabio Borini could be out for up to three months after requiring surgery on a broken foot, whilst Andy Carroll is currently on loan with West Ham.
But the Reds boss said he has not even thought about recalling Carroll from his loan at Upton Park.
"I've rested him a couple of times knowing the squad we have and the games we have, looking to prioritise, but like most footballers he wants to play every minute of every game," said the Northern Irishman.
"It is something I need to assess. The most important thing is winning games - that is what we need to do and in order to do that as often as we can I need the best players on the field.
"Luis will absolutely love playing three times a week but I need to try to nurture him because there are still many games to play between now and January.
"And even in January if we bring someone in it may not be January 1, so that is something which, over time, I need to assess and we'll look to manage the squad."
On Carroll, Rodgers added: "It isn't something I have considered, to be honest.
"Andy has obviously gone out to get games. We have people watching when he plays and they report back on how he is doing.
"But with Fabio's injury just coming up we will assess it from there."