Reina stands behind Agger and Skrtel every week and reckons their partnership will only get stronger after the pair signed new deals this season.
"It's good they've signed contracts because it's a fact that they are one of the best centre-back couples in the Premier League," Reina told Liverpoolfc.com.
"The understanding between them is great and they've been really solid lately. In the last year and a half or so they have been brilliant for us.
"It's great for the club and I'm happy for them that they've got new deals.
"If I am not mistaken they are similar ages to each other, so they have five or six years still to play their best football.
"I don't see any reason why they can't do the same as Carra and Sami did, though they were one of the greatest centre-back couples this club has ever had."