Marcello Lippiâ€™s men destroyed Ranko Popovicâ€™s side at the Nagai Stadium in Osaka to place one foot in the quarter-finals as they go about defending their continental title.
Braces from Brazilian pair Muriqui and Elkeson did the damage for Evergrande who have now won six matches in a row in all competitions.
Pohang Steelers edged K-League rivals Jeonbuk Motors 2-1 in Jeonju thanks to late goals from Son Joo-ho and Go Moo-yul after Lee Jae-sung had opened the scoring for the home side.
Asamoah Gyan netted his eighth goal of the ACL campaign as Al-Ain beat UAE rivals Al-Jazira 2-1 in Abu Dhabi while Saudi Arabiaâ€™s Al-Ittihad got the better of their domestic adversaries Al-Shabab 1-0 in Mecca.
The second lot of Round of 16 fixtures takes place on Wednesday with A-League runners-up Western Sydney Wanderers set to take on Sanfrecce Hiroshima in Japan, South Koreaâ€™s FC Seoul heading to Japanâ€™s Kawasaki Frontale, Uzbekistanâ€™s Bunyodkor hosting Saudi Arabiaâ€™s Al-Hilal and Qatar side Al-Sadd up against Iranâ€™s Foolad.
The return legs of the 2014 Asian Champions Leagueâ€™s Round of 16 take place on Tuesday, May 13 and Wednesday, May 14.
For breaking stories and all the great banter like us on Facebook: facebook.com/tribalfootball