Tottenham boss Harry Redknapp has confirmed Ledley King suffered a knee setback in the friendly against Grays Athletic this week.
Against Wolves, King and Jonathan Woodgate will miss out, although neither are expected to be sidelined for long.
"Ledley jarred his knee again," Redknapp said. "It's blown up and swollen up quite badly.
"It was looking great, he'd worked hard for three weeks. He was just short of a game, unfortunately it was a freak accident - the ball hit him in the face and his knee jarred.
"Hopefully he shouldn't be too long. Woodgate the same."