The former Manchester United winger is focusing on a positive outcome and feels, if his side can take top spot in La Liga, it will have a major psychological effect.
The Portugal international told Marca: "Sevilla is the strongest team we have left. But we must win, it could be very important if we lead the league.
"I could not play the other game (when Sevilla won 2-1 in October) because I was injured, but I really want to play, I feel like it. I hope to do well and we can continue with the style of play that we're offering."
But Real, who have scored 22 goals in winning their last six league games, will face a tough challenge as they go in search of a 13th-straight home win as the visitors have lost just one of their last six league games and currently lie fourth in the standings.
Ronaldo is hopeful that it will not be a case of unlucky 13.
"That number is unlucky in Portugal too. But anyway, I'm not superstitious, we should not think about these things. The only thing that matters is we win. At home we are very solid and hopefully we can build on the good form."