The visitors survived red cards for Fabio Coentrao and Angel Di Maria, and an injury to Iker Casillas, to draw 1-1 in Valencia.
Karim Benzema netted just before halftime to put Jose Mourinho's side 3-0 up in the tie, before Coentrao picked up a second yellow card for a handball in the 51st minute.
Valencia pulled a goal back from the ensuing freekick when Tino Costa's low freekick surprised Real's reserve keeper Antonio Adan.
Adan had to replace Casillas in the 15th minute after Alvaro Arbeloa accidentally kicked his hand while trying to clear a ball.
Casillas was later seen in the dugout with ice on his hand. Di Maria was sent off two minutes from time after kicking out at Valencia defender Joao Pereira as the two tussled for a ball.