The on-loan Manchester City striker has already struck two goals since his arrival.
"It's definitely going to be very difficult," he told the club's official website. "Every team that plays Real Madrid tries their very hardest to beat us.
"We need to just stick to our game and try to score goals. I'm certain that if we do that we can win the match.
"Our main goal is to pick up three points despite the fact that they're a tough side. We have plenty of great players in the squad so if we stick to what we know best then we can win the game."
Ozil also hailed the arrival of striker Adebayor from Manchester City and enthused, "He arrived here from England where he scored a lot of goals.
"He's a top class striker and we knew right from the start that he understood the team well. He's a great guy and I'm very pleased to have him in the squad."